GluN 2 D receptors detect glutamate spillover and regulate cerebellar GABA 1 release
نویسندگان
چکیده
Correspondence should be addressed to: 15 Dr. S.Q. June Liu 16 Department of Cell Biology and Anatomy 17 Louisiana State University Health Sciences Center 18 New Orleans, LA 70112 19 E-mail: [email protected] 20 21 Phone #: (504)-568-2258 22 Fax #: (504) 568-2169 23 24 Acknowledgements: This work was supported by National Science Foundation Grant IBN25 0344559 and National Institutes of Health Grants NS58867 and MH095948 (S.Q.J.L.). We thank 26 Drs. Daniel Monaghan, Matthieu Maroteaux, Iaroslav Savtchouk, Yu Liu, and Matthew Whim for 27 their experimental advice and helpful discussions. 28 Articles in PresS. J Neurophysiol (October 28, 2015). doi:10.1152/jn.00687.2015
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on the tissue being considered. In the present case of the mossy fiber–granule cell glomerulus, spillover augments excitability by activating receptors at neighboring synapses and, therefore, increases the reliability of transmission. In addition, because adjacent granule cells presumably all sense spillover, it might help to synchronize the activity of multiple granule cells. In other tissues,...
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